What is the Future of High Throughput Screening?
نویسندگان
چکیده
منابع مشابه
In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors
Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active molecules. We propose a decision tree that could be adapted to most in vitro HTS.
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 1999
ISSN: 1087-0571,1552-454X
DOI: 10.1177/108705719900400304